sáb. Mar 6th, 2021

La hidroxicloroquina y la azitromicina reducen la carga viral en pacientes con COVID-19

Ya se demostró en 2005 que la reproducción de SARS-CoV-1 en cultivo celular estaba bloqueada por cloroquina, momento en el cual no había infecciones en humanos

La hidroxicloroquina (derivado de la cloroquina) se ha utilizado durante años en el tratamiento de la malaria. También se sabe que el medicamento bloquea la entrada de muchos virus en las células. Un pequeño ensayo clínico llevado a cabo por investigadores franceses de The Méditerranée Infection University Hospital Institute en Marseilla ha revelado que es eficaz para reducir la carga viral en pacientes con COVID-19 .

Philippe Gautret, y su equipo del Hospital Universitario de Marsella  explican que la entrada de virus en las células requiere que las partículas del virus se unan a los receptores de la superficie celular para permitir la liberación del genoma viral en el citoplasma. En muchos casos, después esta unión, llegan a las células a través de la vía endocítica. A medida que estas vesículas se mueven hacia el núcleo, su pH disminuye, lo que cataliza la fusión de las membranas virales y celulares. Cuando las células se tratan con cloroquina, el pH del endosoma se eleva, lo que evita la fusión y bloquea la infección viral. Se sabe que la cloroquina inhibe la reproducción de muchos virus.

Ya se demostró en 2005 que la reproducción de SARS-CoV-1 en cultivo celular estaba bloqueada por cloroquina, momento en el cual no había infecciones en humanos. Recientemente se descubrió que la cloroquina inhibía la reproducción del SARS-CoV-2. Como consecuencia, ahora se ha probado un derivado del medicamento, la hidroxicloroquina (un derivado menos tóxico) en pacientes con COVID-19.

Los pacientes incluidos en el estudio, tenían más de 12 años y tenían infección confirmada por laboratorio con SARS-CoV-2. Recibieron 600 mg diarios de hidroxicloroquina durante diez días. Las cargas virales se midieron diariamente de muestras nasofaríngeas.

Los resultados de este estudio clínico realizado en Marsella, para evaluar la eficacia de la hidroxicloroquina se publican en International Journal of Antimicrobial Agents y recogen que al inicio del tratamiento, los pacientes se dividieron en tres grupos según la presentación clínica: infecciones asintomáticas y del tracto respiratorio superior o inferior. A algunos pacientes también se les administró azitromicina para prevenir la sobreinfección bacteriana.

Al finalizar el estudio, veinte pacientes habían recibido tratamiento y 16 eran controles no tratados. Para el día 6 del estudio, el 70% de los pacientes tratados ya no albergaban virus según lo determinado por RT-PCR, en comparación con el 12,5% de los controles.

La combinación de hidroxicloroquina y azitromicina fue más efectiva para eliminar el virus que la hidroxicloroquina sola.

Los autores concluyen que a pesar del pequeño tamaño de muestra, el estudio indica que el tratamiento con hidroxicloroquina está asociado significativamente con la reducción y desaparición de la carga viral en pacientes con COVID-19 y su efecto es reforzado por azitromicina.


Por notiregio

2,399 comentarios en «¿Una cura para el VIRUS? Combinación de dos medicamentos.»
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  12. We made the decision that it would be Puerto Rico in around five minutes, and after one more 10 we currently had our flight tickets scheduled:-RRB-)))) Our trip lasted 7 days and also obviously, as usual, it was a journey on our very own. We prepared our travel plan ourselves and also selected the places that seemed one of the most interesting to us. In today’s message, I will certainly concentrate on practical details regarding Puerto Rico. Puerto Rico is a reliant area of the USA uncorporated arranged region on the Atlantic Ocean and also the Caribbean Sea. Therefore, tourists from the United States do not need a passport to arrive, a United States driving certificate is quite adequate below. The flight is taken into consideration domestic – so in the case of Atlanta, where the massive airport terminal is divided into domestic and also international trips, we flew normally from the residential one. The money of Puerto Rico is, of course, United States dollars, which was a terrific assistance for us. Furthermore, US mobile networks run typically here. As well as at the very same rates for calls, messages and also network – a blessing, specifically when it pertains to the Web! Especially given that the wifi in many places in Puerto Rico was so negative. The official languages are Spanish and English – however the substantial majority of residents talk rather the previous. Puerto Rico is located in the humid equatorial climate zone, as well as the typical yearly temperature level is around 25 degrees Celsius. The visitor period runs from December 15 to April 15, as well as tropical hefty rains usually take place in the high period. And it turned out to be true – during our week-long stay it really did not rain only one day. The good news is, the rain, although it was putting down, came really promptly as well as after 15-20 mins the storm mored than and also the sun was beaming once again. An interesting reality is that, according to a study carried out as soon as, Puerto Ricans are the happiest country worldwide. If this holds true, it would certainly mean that the well-known declaration that money does not bring joy has a grain of truth in it. It is approximated that nearly half of the occupants of Public Relations deal with hardship, which can be seen while circumnavigating the island. Since Puerto Rico is an island, it is absolutely a plane Or a ship, if you wish to hook up on Public Relations during a cruise ship in the Caribbean. The main airport in San Juan the resources is well gotten in touch with significant US cities. From what I remember, our trip from Atlanta lasted 3 hours It is best to rent out an automobile in Puerto Rico and also circumnavigate the island this way. We had the opportunity to make use of the public Puerto Rico transportation only when, in the form of a ferryboat, and also if all the rest works according to similar rules, I highly encourage this auto than nerve-racking Pointer – it’s truly worth renting out a vehicle with a higher suspension. We did not know concerning it as well as we chose to acquire some small gingerbread as a result of the best rate. We swiftly regretted this decision, because some corners of Puerto Rico are best explored with a 4×4 SUV. Caribbean, an island between the Caribbean Sea and the North Atlantic Ocean, east of the Dominican Republic, tactically located on the Mona Strait – a key path to the Panama Canal; San Juan is one of the biggest and best natural harbors in the Caribbean; a large number of little rivers and also high mountains in the center of the country ensure good watering of the nation; the south coastline is relatively dry; in the north, an abundant strip of coastal plains. No person flies to Puerto Rico to see its air-conditioned federal government structures. You desire enjoyable in the sun. The good news is that Flamenco Coastline will certainly measure up to your visions and afterwards some. Not only does it supply white sand and also blue water that shimmies imminent, however it additionally boasts shower rooms, lifeguards, food booths, volleyball internet and also tourist stations where you can lease devices for points like snorkeling as well as scuba diving. Puerto Rico’s economic climate is among the most dynamically developing in the Caribbean. The diversified sector has plainly outmatched agriculture as the primary driving pressure of the economy and also an income source. Considering that the 1950s, American business have been spending heavily on the island, urged by duty-free accessibility to the US market and tax obligation breaks. The island has US minimum wage laws. Sugar production lost its prominent placement in agriculture to dairy products and animals manufacturing. Tourist is commonly a crucial income, it is estimated that Puerto Rico was seen by nearly 5 million individuals in 2004. 2001-03 saw a decrease in financial growth, generally because of the US economic crisis; in 2004-05 there was an economic development, and also in 2006-07 it dropped once again. Puerto Rico is one of the most dynamically creating Caribbean nations. The diversified sector has actually outshined agriculture and also is currently the major income source. Because the 1950s, American business have actually been investing on the island, encouraged by the duty-free exchange with the U.S.A. and tax obligation incentives. The island is subject to US minimum wage law. Sugar manufacturing reduced, as well as the milk industry and also animals production came to be the primary income. Tourism has been an essential source of income for several years. It is estimated that in 1999 Puerto Rico was seen by 5 million tourists. The diagnosis for 2000 is excellent, provided that the economic boom in the United States and also the growth patterns in tourist as well as construction continue. Every person wanted a piece of the New Globe, and also every person agreed to fight to get it. Nowhere is this even more noticeable than the Castillo San Felipe del Morro. Officially referred to as La Ruta del Lechón, the Pork Highway is exactly what it sounds like: a three-mile stretch of roadway where every dining establishment specializes in pork. The most prominent sort of pork is lechón, an unique recipe in Puerto Rico that includes spit-roasting an entire pig with a blend of sauces and seasonings. Get your blood pumping with a trip to the Toro Verde Theme park in main Puerto Rico. It offers ziplines, rope courses and also rock climbing up difficulties that are ensured to make you pee your trousers a little when you recognize just what you’ve gotten yourself into! The park’s piece de resistance is “The Monster,” which is detailed in the Guinness Publication of World Records as the longest zipline worldwide. With cobbled roads, busy plazas and vibrant residences that stack with each other like foundation of yellow, blue, environment-friendly, orange and also blue-green, Old San Juan is one of one of the most vibrant places to check out in Puerto Rico. This is why locations like Isla Culebrita exist. Isla Culebrita is an uninhabited island off the coastline of eastern Puerto Rico. It’s only about a mile long, and also gain access to is restricted to ferryboats as well as water taxis. Museo de Las Americas There are lots of museums in Puerto Rico, but only a handful are actually about Puerto Rico. The Museo de Las Americas is one of these precious places. It has artifacts, symbols and also textiles from dozens of indigenous teams that stayed in Latin America prior to it was colonized, and also it can take you on a multi-continental trip with history. If you like to eat, Mayaguez is the city for you. It’s house to every little thing from fine dining establishments to open-air cafes with huge, vibrant umbrellas, so you’ll have plenty of alternatives when your stomach starts grumbling. El Yunque National Forestis Treatment greater than 28,000 acres, the El Yunque National Forest is a rich, moist rain forest where dense foliage covers everything from slinking snakes to croaking tree frogs. It’s the only exotic jungle in Puerto Rico, and site visitors originate from around the Carribean to witness both its beauty as well as biodiversity. Situated in the city of Cabo Rojo on the most southern suggestion of Puerto Rico, the Los Morrillos Lighthouse is just one of those lovely areas that you can only discover in the Caribbean. It’s perched in addition to white sedimentary rock cliffs that are surrounded by salt marshes as well as lagoons, and also the waves collision against the high cliffs with a violence that’s stunning however beautiful. Cayo Santiago is a tiny stretch of land off the eastern coast of Puerto Rico.

  13. We made the decision that it would certainly be Puerto Rico in about five minutes, as well as after another 10 we already had our trip tickets scheduled:-RRB-)))) Our trip lasted 7 days and also certainly, as usual, it was a journey on our own. We intended our travel plan ourselves and also selected the locations that appeared the most intriguing to us. In today’s blog post, I will certainly concentrate on functional info concerning Puerto Rico. Puerto Rico is a reliant territory of the United States uncorporated organized region on the Atlantic Ocean and also the Caribbean Sea. Because of this, tourists from the USA do not need a ticket to get there, an US driving permit is rather enough here. The flight is thought about residential – so when it comes to Atlanta, where the huge airport terminal is split into domestic and worldwide trips, we flew usually from the domestic one. The currency of Puerto Rico is, of course, United States dollars, which was an excellent aid for us. In addition, United States mobile networks run usually here. And also at the exact same prices for telephone calls, messages as well as network – a blessing, particularly when it pertains to the Internet! Particularly considering that the wifi in several locations in Puerto Rico was so bad. The official languages are Spanish and also English – however the substantial majority of homeowners talk instead the previous. Puerto Rico lies in the humid equatorial environment zone, and also the ordinary annual temperature level is around 25 degrees Celsius. The visitor period ranges from December 15 to April 15, and tropical hefty rains frequently happen in the high season. And also it turned out to be real – throughout our week-long stay it didn’t rainfall only one day. Luckily, the rain, although it was pouring down, came extremely promptly as well as after 15-20 mins the tornado mored than and the sun was beaming once more. An interesting reality is that, according to a research accomplished when, Puerto Ricans are the happiest nation on the planet. If this is true, it would certainly imply that the famous declaration that money does not bring happiness has a grain of reality in it. It is estimated that virtually half of the residents of PR battle with destitution, which can be seen while traveling around the island. Considering That Puerto Rico is an island, it is absolutely an airplane Or a ship, if you intend to attach on Public Relations throughout a cruise in the Caribbean. The primary flight terminal in San Juan the resources is well gotten in touch with significant US cities. From what I bear in mind, our trip from Atlanta lasted 3 hours It is best to rent a car in Puerto Rico and travel around the island this way. We had the chance to use the general public Puerto Rico transportation just when, in the form of a ferry, and if all the rest functions according to similar regulations, I strongly encourage this vehicle than stressful Suggestion – it’s really worth leasing an automobile with a higher suspension. We did not know regarding it as well as we made a decision to acquire some tiny gingerbread because of the most effective cost. We promptly regretted this decision, because some corners of Puerto Rico are best checked out with a 4×4 SUV. Caribbean, an island in between the Caribbean Sea and also the North Atlantic Sea, east of the Dominican Republic, purposefully located on the Mona Strait – a key path to the Panama Canal; San Juan is among the largest and also ideal natural harbors in the Caribbean; a lot of small rivers as well as high hills in the facility of the country make sure great watering of the nation; the south shore is reasonably dry; in the north, a productive strip of coastal plains. Nobody flies to Puerto Rico to see its cool government structures. You want enjoyable in the sun. The good news is that Flamenco Beach will meet your visions and afterwards some. Not only does it supply white sand as well as blue water that shimmies on the horizon, but it likewise boasts bathrooms, lifeguards, food booths, beach ball internet as well as vacationer terminals where you can rent out tools for things like snorkeling and scuba diving. Puerto Rico’s economic situation is one of the most dynamically establishing in the Caribbean. The varied market has actually clearly outmatched agriculture as the main driving force of the economic climate and an income. Considering that the 1950s, American firms have actually been spending heavily on the island, motivated by duty-free access to the United States market and tax breaks. The island has US minimum wage legislations. Sugar production shed its prominent position in agriculture to milk and also livestock production. Tourism is commonly an essential income, it is estimated that Puerto Rico was seen by almost 5 million individuals in 2004. 2001-03 saw a decline in economic growth, mostly as a result of the United States recession; in 2004-05 there was an economic growth, and also in 2006-07 it fell again. Puerto Rico is among one of the most dynamically developing Caribbean countries. The varied industry has actually outshined agriculture and is now the primary income source. Since the 1950s, American companies have been buying the island, encouraged by the duty-free exchange with the UNITED STATES and tax motivations. The island goes through US minimum wage regulation. Sugar manufacturing lowered, and the dairy market and also animals manufacturing ended up being the main income. Tourist has been a vital source of income for many years. It is approximated that in 1999 Puerto Rico was seen by 5 million travelers. The diagnosis for 2000 is great, gave that the financial boom in the US and also the growth trends in tourism and also construction proceed. Everyone desired a piece of the New Globe, as well as everyone agreed to eliminate to get it. No place is this even more evident than the Castillo San Felipe del Morro. Officially called La Ruta del Lechón, the Pork Freeway is exactly what it seems like: a three-mile stretch of road where every dining establishment focuses on pork. One of the most popular sort of pork is lechón, an unique recipe in Puerto Rico that entails spit-roasting an entire pig with a blend of sauces and also flavors. Get your blood pumping with a journey to the Toro Verde Theme park in main Puerto Rico. It uses ziplines, rope courses and also rock climbing up challenges that are assured to make you pee your trousers a little when you recognize simply what you’ve gotten yourself into! The park’s piece de resistance is “The Beast,” which is listed in the Guinness Book of Globe Records as the lengthiest zipline worldwide. With cobbled roads, busy plazas and also vibrant houses that pile together like foundation of yellow, blue, environment-friendly, orange as well as turquoise, Old San Juan is among one of the most lively locations to visit in Puerto Rico. This is why areas like Isla Culebrita exist. Isla Culebrita is an unoccupied island off the coastline of eastern Puerto Rico. It’s only regarding a mile long, as well as gain access to is limited to ferries as well as water taxis. Museo de Las Americas There are lots of galleries in Puerto Rico, yet only a handful are really about Puerto Rico. The Museo de Las Americas is just one of these priceless places. It has artefacts, tokens as well as textiles from loads of indigenous groups that lived in Latin America prior to it was colonized, as well as it can take you on a multi-continental trip via history. If you like to consume, Mayaguez is the city for you. It’s house to every little thing from great dining establishments to al fresco coffee shops with large, vibrant umbrellas, so you’ll have plenty of alternatives when your tummy starts roaring. El Yunque National Forestis Covering more than 28,000 acres, the El Yunque National Forest is a lush, damp rainforest where thick vegetation covers every little thing from crawling serpents to croaking tree frogs. It’s the only exotic jungle in Puerto Rico, as well as visitors come from all over the Carribean to witness both its appeal as well as biodiversity. Situated in the city of Cabo Rojo on the most southern tip of Puerto Rico, the Los Morrillos Lighthouse is just one of those lovely places that you can just discover in the Caribbean. It’s perched in addition to white sedimentary rock cliffs that are bordered by salt marshes as well as lagoons, and the waves collision versus the cliffs with a physical violence that’s surprising but beautiful. Cayo Santiago is a small stretch of land off the eastern shore of Puerto Rico.

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  20. Did you understand these truths on CBD OIL and Full Spectrum CBD Hemp Oil? Cannabinoids are separated from hemp using supercritical CO2 extraction. Thanks to contemporary innovation, the resulting option is clean, devoid of unnecessary waxes and heavy metals, naturally present in the plant, and the sucked liquid has a common, oily consistency. CBD oil contains cannabidiol as a base active ingredient and may contain just trace amounts of tetrahydroxycannabidiol (THC). It is advised by medical professionals and pharmacists as an antioxidant and substance that obstructs the action of proinflammatory cytokines (proteins), e.g. in Crohn’s illness or ulcerative intestinal tract. RSO oil has a low CBD content, while high THC. The synergistic (enhancing) action of CBD and THC relative to each other is utilized here. Both cannabinoids can do much more together than when utilized individually. Both marijuana oil type CBD and RSO likewise include other cannabinoids, such as cannabichromene (CBC) and cannabigerol (CBG). The trick is not, however, that CBD often has actually a structure expanded to consist of flavones, flavonoids, terpenes, terpenoids, amino acids and omega acids. The distinction is mainly due to intentions guiding humanity to use one or the other item. CBD medical cannabis oil is a rather advantageous blend of cannabinoids, created to secure against 21st century illness. It’s finest to utilize all of these compounds together, as nature produced them and enclosed in cannabis inflorescences. It turns out that cannabidiol boosts the results of cannabichromene (CBC) and cannabigerol (CBG), and flavones or flavonoids enhance the absorption of these compounds. Omega-6 and omega-3 highly nourish the body and do not enable to change, which accelerate the aging process of the organism and enhance the advancement of cancer. Oil of marijuana in a kind of pastime APR contains small amounts of CBD, stabilized by the existence of THC. – Modern clinical research study shows that CBD + THC cope with major autoimmune diseases, while CBC or CBG reveal very little activity in the presence of both substances, just like flavonoids, terpenes or flavones, therefore their material in the service seems to be unnecessary. In addition, the cannabis pressure from which THC and CBD are obtained include negligible amounts of other cannabinoids. Marijuana oil has actually currently marked a brand-new age in which guy ceased to fear what is unknown, and started to uncover what our forefathers had actually currently observed and use the significant potential, at very first look, a little strange relationships, associated mainly with pathology. Medical cannabis, contrary to its name, does not suggest fermented female inflorescences and leaves consisting of psychedelic substances coiled in so-called “Joints”, but an advantageous oil without psychedelic THC. A standard individual, after taking doses of medical cannabis and achieving the appropriate state of cannabinoids in the blood, can delight in increased resistance, lowered susceptibility to cancer, postponed aging and lowered risk of stroke or heart attack. CBD oil consists of cannabidiol as a base ingredient and may contain just trace quantities of tetrahydroxycannabidiol (THC). RSO oil has a low CBD content, while high THC. Both marijuana oil type CBD and RSO likewise include other cannabinoids, such as cannabichromene (CBC) and cannabigerol (CBG). CBD medical marijuana oil is a rather useful mix of cannabinoids, designed to protect versus 21st century disease. Oil of marijuana in a kind of hobby APR consists of small quantities of CBD, stabilized by the existence of THC.

  21. Did you know these realities on CBD OIL and Full Spectrum CBD Hemp Oil? Cannabinoids are separated from hemp using supercritical CO2 extraction. Thanks to modern technology, the resulting option is clean, devoid of unnecessary waxes and heavy metals, naturally present in the plant, and the sucked liquid has a normal, oily consistency. CBD oil contains cannabidiol as a base active ingredient and might include just trace quantities of tetrahydroxycannabidiol (THC). Works as a memory enhancer, improving concentration and coordination of movements, eliminating swelling and reoccurring infections. It enhances the conduction of stimuli in the course of autoimmune diseases (several sclerosis, amyotrophic sclerosis). It is advised by medical professionals and pharmacists as an antioxidant and substance that obstructs the action of proinflammatory cytokines (proteins), e.g. in Crohn’s disease or ulcerative intestinal tract. RSO oil has a low CBD content, while high THC. Naturally, the key job of RSO is to cause a psychedelic impact, although it can also stimulate “ill” brain structures. It deserves understanding that supplements of this type is mainly utilized by people to whom basic therapy does not bring relief in disease. The synergistic (enhancing) action of CBD and THC relative to each other is used here. Both cannabinoids can do a lot more together than when used separately. In addition, they collectively promote the division of non-active nerve cells, nourish the fatty envelope of the nerves, and prevent myelin swelling that causes loss of function in some autoimmune diseases. There are likewise stories where cannabis in its natural form softened spasticity, reduced the frequency of convulsions and seizures, and suppressed undesirable scrapie in Parkinson’s disease. This is where the idea of getting RSO, intended just for chronically ill people, stemmed . Both cannabis oil type CBD and RSO likewise contain other cannabinoids, such as cannabichromene (CBC) and cannabigerol (CBG). The secret is not, however, that CBD typically has actually a composition broadened to consist of flavones, flavonoids, terpenes, terpenoids, amino acids and omega acids. The difference is mainly due to intentions guiding humanity to utilize one or the other product. CBD medical cannabis oil is a rather beneficial mix of cannabinoids, designed to secure versus 21st century illness. It’s finest to utilize all of these substances together, as nature developed them and confined in marijuana inflorescences. It turns out that cannabidiol boosts the effects of cannabichromene (CBC) and cannabigerol (CBG), and flavonoids or flavones enhance the absorption of these compounds. Omega-6 and omega-3 highly nourish the body and do not enable to alter, which speed up the aging procedure of the organism and enhance the development of cancer. Oil of cannabis in a kind of pastime APR includes percentages of CBD, stabilized by the presence of THC. Producers focus on the synergistic result of one substance relative to the other, while deserting the existence of CBC and CBG. Why such a choice? – Modern scientific research study reveals that CBD + THC cope with major autoimmune illness, while CBC or CBG show minimal activity in the existence of both compounds, simply like flavonoids, flavones or terpenes, therefore their content in the option appears to be unneeded. In addition, the cannabis pressure from which THC and CBD are derived include negligible amounts of other cannabinoids. RSO oil is entirely illegal in Poland, which is why it can not be obtained in any lawfully running shop on the marketplace. Naturally, there are a variety of amateur methods for acquiring it, however it’s great to know that substances obtained synthetically in house laboratories are uncertain, untried, and the impact unknown. The solvent for the production of household RSO is normally fuel, alcohol and even kerosene, which rather of curing, poison. Alcohols and their like hinder cannabinoids, therefore in reality, they don’t bring anything brand-new to the medical world. Marijuana oil has already marked a brand-new period in which man ceased to fear what is unknown, and began to rediscover what our ancestors had actually currently discovered and utilize the significant capacity, at first look, a little unusual relationships, associated generally with pathology. Medical cannabis, contrary to its name, does not indicate fermented female inflorescences and leaves including psychoactive compounds coiled in so-called “Joints”, but an useful oil without psychedelic THC. A basic individual, after taking dosages of medical marijuana and accomplishing the suitable state of cannabinoids in the blood, can enjoy increased immunity, reduced susceptibility to cancer, delayed aging and lowered danger of stroke or cardiac arrest. CBD oil contains cannabidiol as a base active ingredient and may consist of only trace amounts of tetrahydroxycannabidiol (THC). RSO oil has a low CBD content, while high THC. Both marijuana oil type CBD and RSO also consist of other cannabinoids, such as cannabichromene (CBC) and cannabigerol (CBG). CBD medical marijuana oil is a rather helpful blend of cannabinoids, developed to secure versus 21st century illness. Oil of marijuana in a kind of pastime APR consists of little quantities of CBD, balanced by the existence of THC.

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